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KMID : 1150720180070040328
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Integrative Medicine Research
2018 Volume.7 No. 4 p.328 ~ p.332
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Effects of Herbal combination (Melissa officinalis L. and Nepeta menthoides Boiss. & Buhse) on insomnia severity, anxiety and depression in insomniacs: Randomized placebo controlled trial
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Ranjbar Maryam
Firoozabadi Ali
Salehi Alireza
Ghorbanifar Zahra
Zarshenas Mohammad M.
Sadeghniiat-Haghighi Khosro
Rezaeizadeh Hossein
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Abstract
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Background: Insomnia is a prevalent disorder leading to psychological problems such as anxiety and depression.
Methods: This study investigates the effect of a combination of herbs (Melissa officinalis L. and Nepeta menthoides Boiss. & Buhse) on anxiety and depression for insomniacs and on insomnia severity. This study is a double-blind randomized placebo-controlled clinical trial. A total number of 67 participants met the inclusion criteria who were diagnosed as cases of insomnia. The patients were randomized into the herbal treatment or placebo groups. The herbal treatment group received a combination of Melissa officinalis and Nepeta menthoides Boiss. & Buhse. The primary outcomes were insomnia, depression and anxiety. We used per-protocol analysis.
Results: The all outcomes of herbal treatment were significantly improved compared with placebo in the ISI, BAI and BDI scores after four weeks’ treatment (p value: 0.008, 0.005 and <0.001 respectively).
Conclusion: A combination of Melissa officinalis L. and Nepeta menthoides Boiss. & Buhse may improve insomnia and its comorbid depression and anxiety.
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KEYWORD
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Anxiety, Depression, Insomnia, Melissa officinalis, Nepeta menthoides
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